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Silk protein fiber imakhala ndi zinthu zambiri za hydrophilic monga magulu a amino ndi magulu amino, omwe amakhala ndi mayamwidwe amphamvu a chinyezi ndi kumasulidwa, omwe amatha kuwongolera chinyezi pakhungu ndikusunga khungu loyera.Mwa iwo, mitundu 8 ya ma amino acid ofunikira imatha kukulitsa magwiridwe antchito a epithelial cell ndikudyetsa khungu.

Amino acid, tyrosine ndi tryptophan mu silika wa silika ali ndi mphamvu zoteteza ku ultraviolet ndipo amatha kuteteza bwino kuwala kwa ultraviolet.

Chigawo cha sericin cha silika chimatha kuteteza kukula kwa nthata ndi nkhungu, ndipo chimakhala ndi antibacterial ndi khungu komanso anti-allergenic zotsatira.

Lysine yomwe ili mu silika imatha kufulumizitsa kagayidwe ka lipid filimu pamwamba pa khungu, kumapangitsa kuti khungu likhale lolimba, komanso kuti khungu lisawume ndi makwinya.